d p cl phe6 Search Results


[d-p-cl-phe6,leu17]-vip  (TargetMol)
N/A
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[d-p-cl-phe6,leu17]-vip  (MedChemExpress)
N/A
[D-p-Cl-Phe6,Leu17]-VIP TFA is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP TFA has no activity on glucagon, secretin or GRF receptors.
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vip receptor antagonist compound  (Tocris)
91
Tocris vip receptor antagonist compound
(A) Representative images of brains of 2-month-old mice exposed to vehicle or 2 μg/g <t>VIP</t> antagonist <t>from</t> <t>E9.5–E11.5.</t> (B) Quantification of brain mass in 2-month-old mice that were treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the brain mass of one mouse (n = 9 vehicle and n = 8 VIP antagonist). Mean ± SEM. Unpaired t test. (C and D) Representative images (C) and quantification (D) of cortical thickness in E18.5 control and C9ORF72 -BAC embryos treated with vehicle or 2 μg/g VIP antagonist using immunohistochemistry. Each data point represents the average cortical thickness in one embryo (n = 3 control and 3 C9ORF72 -BAC embryos). The average cortical thickness was determined by measuring the width from layer 1 to layer 6 across 3 different 16-mm sections beginning at approximately bregma + 3.51. Mean ± SEM. One-way ANOVA. Scale bars, 1 mm. (E) Quantification of time to fall in a hanging wire test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the average time to fall for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. Kruskal-Wallis test. (F) Quantification of total distance traveled during an open field test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the total distance traveled for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. two-way ANOVA.
Vip Receptor Antagonist Compound, supplied by Tocris, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/d+p+cl+phe6/pmc10757587-400-14-18?v=Tocris
Average 91 stars, based on 1 article reviews
vip receptor antagonist compound - by Bioz Stars, 2026-08
91/100 stars
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vip antagonist d p cl phe6 leu17 vip  (Tocris)
93
Tocris vip antagonist d p cl phe6 leu17 vip
(A) Representative images of brains of 2-month-old mice exposed to vehicle or 2 μg/g <t>VIP</t> antagonist <t>from</t> <t>E9.5–E11.5.</t> (B) Quantification of brain mass in 2-month-old mice that were treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the brain mass of one mouse (n = 9 vehicle and n = 8 VIP antagonist). Mean ± SEM. Unpaired t test. (C and D) Representative images (C) and quantification (D) of cortical thickness in E18.5 control and C9ORF72 -BAC embryos treated with vehicle or 2 μg/g VIP antagonist using immunohistochemistry. Each data point represents the average cortical thickness in one embryo (n = 3 control and 3 C9ORF72 -BAC embryos). The average cortical thickness was determined by measuring the width from layer 1 to layer 6 across 3 different 16-mm sections beginning at approximately bregma + 3.51. Mean ± SEM. One-way ANOVA. Scale bars, 1 mm. (E) Quantification of time to fall in a hanging wire test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the average time to fall for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. Kruskal-Wallis test. (F) Quantification of total distance traveled during an open field test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the total distance traveled for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. two-way ANOVA.
Vip Antagonist D P Cl Phe6 Leu17 Vip, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/d+p+cl+phe6/pm27090819-59-7-11?v=Tocris
Average 93 stars, based on 1 article reviews
vip antagonist d p cl phe6 leu17 vip - by Bioz Stars, 2026-08
93/100 stars
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d -phe 6 ,leu(®)- p -chloro-phe l4 ]-bombesin(6-14)  (Bachem)
90
Bachem d -phe 6 ,leu(®)- p -chloro-phe l4 ]-bombesin(6-14)
(A) Representative images of brains of 2-month-old mice exposed to vehicle or 2 μg/g <t>VIP</t> antagonist <t>from</t> <t>E9.5–E11.5.</t> (B) Quantification of brain mass in 2-month-old mice that were treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the brain mass of one mouse (n = 9 vehicle and n = 8 VIP antagonist). Mean ± SEM. Unpaired t test. (C and D) Representative images (C) and quantification (D) of cortical thickness in E18.5 control and C9ORF72 -BAC embryos treated with vehicle or 2 μg/g VIP antagonist using immunohistochemistry. Each data point represents the average cortical thickness in one embryo (n = 3 control and 3 C9ORF72 -BAC embryos). The average cortical thickness was determined by measuring the width from layer 1 to layer 6 across 3 different 16-mm sections beginning at approximately bregma + 3.51. Mean ± SEM. One-way ANOVA. Scale bars, 1 mm. (E) Quantification of time to fall in a hanging wire test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the average time to fall for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. Kruskal-Wallis test. (F) Quantification of total distance traveled during an open field test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the total distance traveled for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. two-way ANOVA.
D Phe 6 ,Leu(®) P Chloro Phe L4 ] Bombesin(6 14), supplied by Bachem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/d+p+cl+phe6/pmc01573796-100-1-32?v=Bachem
Average 90 stars, based on 1 article reviews
d -phe 6 ,leu(®)- p -chloro-phe l4 ]-bombesin(6-14) - by Bioz Stars, 2026-08
90/100 stars
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antagonist [ d-p-cl-phe6, leu17]-vip sc923  (PolyPeptide Laboratories)
90
PolyPeptide Laboratories antagonist [ d-p-cl-phe6, leu17]-vip sc923
(A) Representative images of brains of 2-month-old mice exposed to vehicle or 2 μg/g <t>VIP</t> antagonist <t>from</t> <t>E9.5–E11.5.</t> (B) Quantification of brain mass in 2-month-old mice that were treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the brain mass of one mouse (n = 9 vehicle and n = 8 VIP antagonist). Mean ± SEM. Unpaired t test. (C and D) Representative images (C) and quantification (D) of cortical thickness in E18.5 control and C9ORF72 -BAC embryos treated with vehicle or 2 μg/g VIP antagonist using immunohistochemistry. Each data point represents the average cortical thickness in one embryo (n = 3 control and 3 C9ORF72 -BAC embryos). The average cortical thickness was determined by measuring the width from layer 1 to layer 6 across 3 different 16-mm sections beginning at approximately bregma + 3.51. Mean ± SEM. One-way ANOVA. Scale bars, 1 mm. (E) Quantification of time to fall in a hanging wire test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the average time to fall for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. Kruskal-Wallis test. (F) Quantification of total distance traveled during an open field test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the total distance traveled for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. two-way ANOVA.
Antagonist [ D P Cl Phe6, Leu17] Vip Sc923, supplied by PolyPeptide Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/d+p+cl+phe6/pm22054597-45-10-15?v=PolyPeptide+Laboratories
Average 90 stars, based on 1 article reviews
antagonist [ d-p-cl-phe6, leu17]-vip sc923 - by Bioz Stars, 2026-08
90/100 stars
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non-selective vip receptor antagonist [ d -p-cl-phe 6 ,leu 17 ]-vip  (Chemie GmbH)
90
Chemie GmbH non-selective vip receptor antagonist [ d -p-cl-phe 6 ,leu 17 ]-vip
(A) Representative images of brains of 2-month-old mice exposed to vehicle or 2 μg/g <t>VIP</t> antagonist <t>from</t> <t>E9.5–E11.5.</t> (B) Quantification of brain mass in 2-month-old mice that were treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the brain mass of one mouse (n = 9 vehicle and n = 8 VIP antagonist). Mean ± SEM. Unpaired t test. (C and D) Representative images (C) and quantification (D) of cortical thickness in E18.5 control and C9ORF72 -BAC embryos treated with vehicle or 2 μg/g VIP antagonist using immunohistochemistry. Each data point represents the average cortical thickness in one embryo (n = 3 control and 3 C9ORF72 -BAC embryos). The average cortical thickness was determined by measuring the width from layer 1 to layer 6 across 3 different 16-mm sections beginning at approximately bregma + 3.51. Mean ± SEM. One-way ANOVA. Scale bars, 1 mm. (E) Quantification of time to fall in a hanging wire test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the average time to fall for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. Kruskal-Wallis test. (F) Quantification of total distance traveled during an open field test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the total distance traveled for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. two-way ANOVA.
Non Selective Vip Receptor Antagonist [ D P Cl Phe 6 ,Leu 17 ] Vip, supplied by Chemie GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/d+p+cl+phe6/pmc01572383-132-12-27?v=Chemie+GmbH
Average 90 stars, based on 1 article reviews
non-selective vip receptor antagonist [ d -p-cl-phe 6 ,leu 17 ]-vip - by Bioz Stars, 2026-08
90/100 stars
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phenylacetyl-(d-arg2·28,p-chloro-phe6,arg9, abu 15, nle 27, homoarg 29)-grf (1-29) amide  (Biosynth Carbosynth)
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[d-p-cl-phe6,leu17]-vip  (BOC Sciences)
N/A
[D-p-Cl-Phe6,Leu17]-VIP is a selective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM) with no activity at glucagon, secretin or GRF receptors.
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[d-p-cl-phe6,leu17]-vip tfa  (TargetMol)
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[d-p-cl-phe6,leu17]-vip acetate  (TargetMol)
N/A
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phenylacetyl-(d-arg2·28,p-chloro-phe6, homoarg 9·29,tyr(me)10, abu 15, nle 27)-grf (1-29) amide  (Biosynth Carbosynth)
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Image Search Results


(A) Representative images of brains of 2-month-old mice exposed to vehicle or 2 μg/g VIP antagonist from E9.5–E11.5. (B) Quantification of brain mass in 2-month-old mice that were treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the brain mass of one mouse (n = 9 vehicle and n = 8 VIP antagonist). Mean ± SEM. Unpaired t test. (C and D) Representative images (C) and quantification (D) of cortical thickness in E18.5 control and C9ORF72 -BAC embryos treated with vehicle or 2 μg/g VIP antagonist using immunohistochemistry. Each data point represents the average cortical thickness in one embryo (n = 3 control and 3 C9ORF72 -BAC embryos). The average cortical thickness was determined by measuring the width from layer 1 to layer 6 across 3 different 16-mm sections beginning at approximately bregma + 3.51. Mean ± SEM. One-way ANOVA. Scale bars, 1 mm. (E) Quantification of time to fall in a hanging wire test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the average time to fall for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. Kruskal-Wallis test. (F) Quantification of total distance traveled during an open field test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the total distance traveled for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. two-way ANOVA.

Journal: Cell reports

Article Title: The C9ORF72 repeat expansion alters neurodevelopment

doi: 10.1016/j.celrep.2023.112983

Figure Lengend Snippet: (A) Representative images of brains of 2-month-old mice exposed to vehicle or 2 μg/g VIP antagonist from E9.5–E11.5. (B) Quantification of brain mass in 2-month-old mice that were treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the brain mass of one mouse (n = 9 vehicle and n = 8 VIP antagonist). Mean ± SEM. Unpaired t test. (C and D) Representative images (C) and quantification (D) of cortical thickness in E18.5 control and C9ORF72 -BAC embryos treated with vehicle or 2 μg/g VIP antagonist using immunohistochemistry. Each data point represents the average cortical thickness in one embryo (n = 3 control and 3 C9ORF72 -BAC embryos). The average cortical thickness was determined by measuring the width from layer 1 to layer 6 across 3 different 16-mm sections beginning at approximately bregma + 3.51. Mean ± SEM. One-way ANOVA. Scale bars, 1 mm. (E) Quantification of time to fall in a hanging wire test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the average time to fall for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. Kruskal-Wallis test. (F) Quantification of total distance traveled during an open field test for 2-month-old control and C9ORF72 -BAC mice treated with vehicle or VIP antagonist from E9.5–E11.5. Each data point represents the total distance traveled for one mouse. Control + vehicle, n = 11 mice; control + VIP antagonist, n = 10 mice; C9ORF72 -BAC + vehicle, n = 10 mice; C9ORF72 -BAC + VIP antagonist, n = 16 mice. Mean ± SEM. two-way ANOVA.

Article Snippet: Pregnant dams were administered intraperitoneal (IP) injections of 2 μg/g body weight of the VIP receptor antagonist compound (Tocris, cat. no. 3054) once a day at E9.5, E10.5, and E11.5.

Techniques: Control, Immunohistochemistry